Thesis (M.Sc.) -- University of Toronto, 2002.
|Series||Canadian theses = -- Th`eses canadiennes|
|The Physical Object|
|Pagination||2 microfiches : negative.|
Centromeres in the budding yeast Saccharomyces cerevisiae are the best studied and understood. S. cerevisiae centromeres are encoded by three distinct DNA elements (CDE I, II, and III) within a bp region (Figure 1).Two elements (CDE I and III) are absolutely conserved and required to recruit centromere and kinetochore proteins. The centromeric histone CENP-A (Cse4p) is recruited to CDE . In book: eLS; Project: centromeric domains, as well as to recruit cohesin proteins Every eukaryotic chromosome has a centromere, the locus responsible for poleward movement at mitosis and. Centromeric Organization A repetitive problem. At repetitive regions, which make up the majority of many genomes including the human genome [15,16], the specific localization and properties of RNA transcripts cannot be assigned using RNA sequencing approaches designed for unique-sequence parts of the genome [17,18].This contrasts with the precise localization of unique sequence RNAs, Cited by: 2. However, flanking heterochromatin behaves as a domain that is structurally and functionally distinct from CENP-A-containing centromeric chromatin in S. pombe, flies, and humans (Partridge et al., ). Further evidence for the existence of distinct domains within the centromere comes from our observation that chromatin immediately flanking.
Human centromeric alphoid domains are periodically homogenized so that they vary substantially between homologues. Mechanism and implications for centromere functioning. Nucleic Acids Res – [PMC free article] Ross MT, Grafham DV, Coffey AJ, Scherer S, McLay K, Muzny D, Platzer M, Howell GR, Burrows C, Bird CP, et al. The physical role of the centromere is to act as the site of assembly of the kinetochores – a highly complex multiprotein structure that is responsible for the actual events of chromosome segregation – i.e. binding microtubules and signalling to the cell cycle machinery when all chromosomes have adopted correct attachments to the spindle, so that it is safe for cell division to proceed to. The True Believer: Thoughts On The Nature Of Mass Movements is a non-fiction book authored by American philosopher Eric hed in , it depicts a variety of arguments in terms of applied world history and social psychology to explain why mass movements arise to challenge the status quo. Hoffer discusses the sense of individual identity and the holding to particular ideals that can. Book 1 Domains of development For every child, all the domains of development – physical, social, emotional, cognitive and language – develop together. One part (one domain) can’t develop without the others and if one part is slow to develop it will affect all the other parts of the child’s development. A child’s development is.
chromosome movement in mitosis through spindle fibers that are connected to the chromosomes. The kinetochore includes the structural componentsat the site ofattachment ofthe spindle fibers andis located within aunique chromo-somal domain, the centromere. During mitosis, the centromere region is observed as the primary constriction. The centromere is a chromosomal locus that regulates the proper pairing and segregation of the chromosomes during cell division. Despite their conserved, essential function, centromeres are characterized by the rapid evolution of both centromeric DNA and proteins. This book presents current views on centromere structure and identity. The centromeric histone H3 (CENH3) substitutes histone H3 within the nucleosomes of active centromeres in all eukaryotes. CENH3 deposition at centromeres is needed to assemble the kinetochore, a complex of conserved proteins responsible for correct chromosome segregation during nuclear division. Histones of regular nucleosomes are loaded during replication in S phase, while CENH3 deposition. Centromere, structure in a chromosome that holds together the two chromatids (the daughter strands of a replicated chromosome). The centromere is the point of attachment of the kinetochore, a structure to which the microtubules of the mitotic spindle become anchored. The spindle is the structure.